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Probacine
- Development stage
- Preclinical
- Lead developer
- Nanjing Medical University
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
**Probacine** is an investigational oral intestinal microbiota transplant capsule product being studied by Nanjing Medical University as a perioperative gut-microbiome intervention in adults undergoing cardiovascular surgery with cardiopulmonary bypass. In the randomized, double-blind PANDA IV study, it is administered three times daily immediately after surgery for at least 7 days alongside standard care, with the aim of mitigating adverse postoperative gut metabolic changes and organ dysfunction through restoration or modulation of intestinal microbial ecology. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04444362))
- Other names
- Intestinal Microbiota Transplant capsulesIMT capsules
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