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Probimel

Development stage: Unknown
Lead developer: Desarrollo de Alimentos Fermentados
Modality: Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral

Overview

Probimel is a commercial multi-strain probiotic supplement manufactured by Laboratorios Melder. It contains a blend of beneficial bacteria, including *Lactobacillus acidophilus*, *Lactobacillus casei*, *Lactobacillus rhamnosus*, *Lactobacillus plantarum*, *Bifidobacterium infantis*, *Bifidobacterium lactis*, *Bifidobacterium longum*, and *Streptococcus thermophilus*. In the context of chronic kidney disease (CKD), it has been investigated for its potential to modulate the gut-kidney axis, reduce uremic toxins like indoxyl sulfate, and lower pro-inflammatory cytokines such as interleukin-6 (IL-6) and interferon-gamma (IFN-γ). While experimental models showed some reduction in inflammation and uremic toxins, clinical studies in patients with advanced CKD have not demonstrated significant improvements in kidney function or vascular calcification.

Brand names: Probimel

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