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Probiotic Cocktail A
- Development stage
- Preclinical
- Lead developer
- Chulalongkorn University
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Probiotic Cocktail A is a synbiotic formulation developed by researchers at Chulalongkorn University. It consists of 10^9 CFU of *Bifidobacterium longum* TCU1 and *Ligilactobacillus salivarius* TCUA (formerly *Lactobacillus salivarius* TCUA), combined with the prebiotics inulin and chitosan oligosaccharide (COS). The cocktail is designed to promote gut barrier integrity by increasing the expression of the tight junction protein zonula occludens-1 (ZO-1) and exerting anti-inflammatory effects. In preclinical models of chronic kidney disease (CKD), Probiotic Cocktail A has demonstrated therapeutic potential in reducing paracellular intestinal phosphate absorption, thereby ameliorating hyperphosphatemia and secondary hyperparathyroidism without altering serum calcium levels.
- Other names
- Cocktail A
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