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probiotic prawn oral immunotherapy
- Development stage
- Unknown
- Lead developer
- Murdoch Children's Research Institute
- Modality
- Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Probiotic prawn oral immunotherapy (ProPIT) is an investigational allergen-specific immunotherapy developed by the Murdoch Children's Research Institute for the treatment of IgE-mediated prawn allergy. The therapy utilizes the Probiotic and Food Oral Immunotherapy (PPOIT) platform, which combines the administration of prawn allergen proteins (primarily tropomyosin) with a probiotic (typically *Lactobacillus rhamnosus* CGMCC 1.3724) to modulate the immune system. The goal is to induce clinical desensitization or sustained unresponsiveness by shifting the immune response from a Th2-mediated allergic profile to a more tolerant state. It is currently being evaluated in the Phase 2b PIPA trial.
- Other names
- prawn oral immunotherapyprawn OITprobiotic prawn OIT
02
Targets
MHC II (Major histocompatibility complex class II receptor)Immunoglobulin E (specific to prawn tropomyosin)sIgE-tropomyosin (Immunoglobulin E specific for cross-reactive invertebrate tropomyosins)TCR (T cell antigen receptor complex)Prawn tropomyosin-specific B-cell receptor
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