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probiotic-Tongji Hospital

Development stage: Unknown
Lead developer: Tongji Hospital
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral

Overview

probiotic-Tongji Hospital refers to the oral probiotic intervention utilized by Tongji Hospital in clinical protocols for the conservative management of Hirschsprung disease (HD) in infants. In this context, the probiotic is administered as part of a multi-modal conservative regimen—including anal dilation and colonic lavage—aimed at improving constipation symptoms and potentially avoiding or delaying surgical intervention in patients with short-segment or normal-segment HD. Probiotics function by modulating the intestinal microbiota, enhancing gut barrier function, and potentially improving colonic motility through the production of short-chain fatty acids and interaction with the enteric nervous system. The specific strains used in the Tongji Hospital protocol are not explicitly named in the trial context, but the intervention is evaluated for its efficacy in reducing the need for one-stage pull-through surgery.

Other names: oral probiotic

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