probiotics + methotrexate

This combination therapy consists of oral probiotics and the systemic immunosuppressant methotrexate. It is being investigated by Alexandria University as a treatment for newly diagnosed chronic plaque psoriasis. The study aims to determine if probiotics can enhance the clinical response to methotrexate and mitigate its impact on the gut microbiome, potentially by increasing beneficial bacteria and decreasing harmful strains. Methotrexate acts as a folic acid antagonist and immunosuppressant by inhibiting dihydrofolate reductase, while the probiotics serve as a live biotherapeutic to modulate the gut-skin axis.

Other names

Probiotics and methotrexate