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probiotics + polygonatum sibiricum
- Development stage
- Preclinical
- Lead developer
- Jiangxi Agricultural University
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
The combination of probiotics and *Polygonatum sibiricum* (also known as Huangjing) is a synbiotic formulation that pairs live beneficial microorganisms with the bioactive extracts of a traditional Chinese medicinal herb. *Polygonatum sibiricum* is rich in polysaccharides, which serve as prebiotics by selectively promoting the growth and metabolic activity of probiotic strains such as *Lactobacillus* and *Bifidobacterium*. This combination is primarily investigated for its synergistic effects on gut microbiota modulation, enhancement of intestinal barrier function, and regulation of metabolic health. Research indicates that this pairing may be effective in managing type 2 diabetes, obesity, and non-alcoholic fatty liver disease (NAFLD) by improving insulin sensitivity, reducing systemic inflammation, and restoring microbial diversity in the gastrointestinal tract.
- Other names
- Huangjing probioticsPolygonatum sibiricum polysaccharides + probioticssynbiotic probiotics and Polygonatum sibiricum
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