processed amniotic fluid

Processed amniotic fluid (pAF) is an acellular, sterile biologic allograft derived from human amniotic fluid, typically harvested during scheduled Cesarean sections. The processing involves removing cellular components to minimize immunogenicity while preserving a concentrated milieu of regenerative factors, including cytokines, growth factors (such as TGF-β and EGF), and extracellular matrix proteins. It is designed to modulate the local inflammatory environment, specifically by reducing pro-inflammatory cytokines like interleukin-6 (IL-6) and regulating matrix metalloproteinases. Clinical development focuses on its potential to expedite healing in chronic wounds, manage degenerative joint conditions like osteoarthritis, and treat musculoskeletal injuries such as Achilles tendinopathy.

Brand names

AscentAmniomatrix

Other names

pAFacellular amniotic fluidamniotic fluid-derived allograftsterile amniotic fluid