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Procyclidine
- Development stage
- Unknown
- Lead developer
- GSK
- Modality
- Small Molecules
- Administration
- Oral, Intramuscular, Intravenous
01
Overview
Procyclidine is a synthetic anticholinergic and antispasmodic drug primarily used to treat Parkinson's disease and to manage extrapyramidal symptoms, such as stiffness, tremors, spasms, and poor muscle control caused by antipsychotic medications. It acts mainly by blocking muscarinic acetylcholine receptors in the central nervous system, thereby reducing the excitatory effects of acetylcholine and helping to restore the balance between cholinergic and dopaminergic activity in the basal ganglia. Procyclidine is considered a second-line agent for Parkinson's disease, particularly effective for tremor but less so for rigidity or bradykinesia. It may also be used in treating akathisia and acute dystonia[1][2][3][4][5][6].
- Brand names
- Kemadrin
02
Targets
M1 (Muscarinic acetylcholine receptor M1)CHRM2 (M2)CHRM4 (M4)
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