prodigiosene ethyl ester 1a

prodigiosene ethyl ester 1a is a synthetic C-ring ester-functionalized analog of the natural tripyrrolic pigment prodigiosin. Developed by researchers at Dalhousie University, it acts as a transmembrane anion transporter (specifically facilitating H+/Cl- symport) and uncouples vacuolar-type H+-ATPase (V-ATPase) activity, leading to intracellular acidification and the induction of apoptosis in cancer cells. Additionally, it exhibits copper-mediated double-stranded DNA cleavage. It has demonstrated potent in vitro antiproliferative activity against various cancer cell lines, including breast, colon, lung, leukemia, melanoma, and prostate cancers, and serves as a key synthetic precursor for generating targeted prodigiosene conjugates (such as those linked to estrone, tamoxifen, or folate).

Other names

ethyl ester prodigiosene 1aprodigiosene 1aprodigiosene1aprodigiosene-1a