prohibitin peptides

Prohibitin peptides are synthetic peptides derived from the coiled-coil domain (amino acids 175-217) of the tumor suppressor protein prohibitin-1 (PHB1). These peptides, which include the 42-mer H1-6, 14-mers (H1-2, H3-4, H5-6), and 7-mers (H2, H5), are designed to mimic the E2F1-binding domain of prohibitin. By mimicking this domain, the peptides repress E2F1-mediated transcription, recruit histone deacetylase 1 (HDAC1), and arrest cell proliferation. Preclinical studies demonstrate that prohibitin peptides induce apoptosis in breast, lung, and prostate cancer cell lines, reduce the invasive capability of cancer cells, and inhibit angiogenesis in endothelial cells, while sparing normal epithelial cells.

Other names

H1-2H-1-2H 1-2H1-6H-1-6H 1-6H2H-2H 2H3-4H-3-4H 3-4H5H-5H 5H5-6H-5-6H 5-6prohibitin-derived peptides