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proline-arginine-hydroxymethyl rhodamine green
- Development stage
- Preclinical
- Lead developer
- The University of Tokyo
- Modality
- Peptides, Small Molecules
- Administration
- Topical
01
Overview
PR-HMRG is a novel, spray-type fluorescent probe developed for the intraoperative rapid detection of malignant glioma, specifically glioblastoma. It consists of a hydroxymethyl rhodamine green (HMRG) fluorescent scaffold conjugated to a proline-arginine dipeptide. The probe is designed to be enzymatically activated by Calpain-1, a protease that is significantly overexpressed in glioma tumor tissues. Upon cleavage of the dipeptide by Calpain-1, the HMRG scaffold becomes highly fluorescent, allowing for real-time visualization of tumor margins during surgery. This probe aims to address limitations of current surgical adjuncts like 5-aminolevulinic acid (5-ALA), such as false results and the inability to re-administer the agent during a single procedure.
- Other names
- proline-arginine-HMRG
02
Targets
CAPN (Schistosoma calpain large subunit family)
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