Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
proline-arginine-hydroxymethyl rhodamine green
- Development stage
- Preclinical
- Lead developer
- The University of Tokyo
- Modality
- Small Molecules, Peptides
- Administration
- Topical
01
Overview
PR-HMRG is a novel, spray-type fluorescent probe developed for the intraoperative rapid detection of malignant glioma, specifically glioblastoma. It consists of a hydroxymethyl rhodamine green (HMRG) fluorescent scaffold conjugated to a proline-arginine dipeptide. The probe is designed to be enzymatically activated by Calpain-1, a protease that is significantly overexpressed in glioma tumor tissues. Upon cleavage of the dipeptide by Calpain-1, the HMRG scaffold becomes highly fluorescent, allowing for real-time visualization of tumor margins during surgery. This probe aims to address limitations of current surgical adjuncts like 5-aminolevulinic acid (5-ALA), such as false results and the inability to re-administer the agent during a single procedure.
- Other names
- proline-arginine-HMRG
02
Targets
CAPN (Schistosoma calpain large subunit family)
Beyond the preview
Go deeper on proline-arginine-hydroxymethyl rhodamine green.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on proline-arginine-hydroxymethyl rhodamine green.