proline dithiocarbamate

Proline dithiocarbamate (PDTC) is a small molecule compound formed as a dithiocarbamate derivative of the amino acid proline. It has been studied for its **anticancer (chemopreventive)** properties, notably in animal models, where it demonstrated a significant reduction in hepatocellular carcinoma incidence when administered as a chemopreventive agent alongside a carcinogen[1][3]. Its mechanism is based on chelation of metals and radical scavenging, typical of the dithiocarbamate class, likely interfering with carcinogenic pathways. PDTC is also used as a ligand for metal complexes, which can significantly alter its biological properties and have been investigated (e.g., as copper(II) or zinc(II) complexes) for anticancer applications, showing cytotoxic activity in vitro[5][11]. No primary developer or manufacturer is associated as it is primarily a research chemical.

Other names

L-proline, 1-(dithiocarboxy)-N-dithiocarboxy-L-prolineprolinedithiocarbamate