proline-type fullerene derivative P3

Proline-type fullerene derivative P3 is a water-soluble chemical compound derived from the functionalization of a C60 fullerene core with three carboxy groups and proline moieties. It has been studied for its biological activity in inhibiting adipogenesis (the formation of fat cells) in vitro. Specifically, it suppresses lipid accumulation and the expression of adipocyte-specific genes such as aP2 in preadipocyte cell models by preventing activation of peroxisome proliferator-activated receptor gamma (PPARγ), a key regulator of adipocyte differentiation. Unlike other related derivatives with only two carboxy groups, the tri-carboxylated structure of P3 is critical for its anti-adipogenic effect. The compound has shown potential anti-obesity activity at the cellular level but does not affect upstream regulators like C/EBPδ or C/EBPβ[1].

Other names

P3 fullereneP-3 fullereneP 3 fullereneproline-type C60 derivative P3