Drug intelligence / Profile preview

Promescent

Development stage
Phase 3
Lead developer
Absorption Pharmaceuticals
Modality
Small Molecules
Administration
Topical
01

Overview

Promescent is a topical desensitizing spray containing lidocaine, specifically formulated for the treatment of premature ejaculation. It functions as a local anesthetic that reduces sensitivity in the penis by numbing the sensory nerves, thereby delaying ejaculation. Originally developed by Dr. Ron Gilbert, the product is marketed as an over-the-counter (OTC) drug under the FDA monograph for male genital desensitizing products. A Phase 3 clinical trial (NCT02241460) was conducted by Dr. Eugene Y. Rhee to evaluate its efficacy and safety compared to placebo.

Brand names
Promescent
Other names
Promescent Lidocaine Spray
02

Targets

GABRR (GABA-A receptor subunit rho)SCN10A (Sodium channel protein type X alpha subunit)SCN2A (Voltage-gated sodium channel protein type 2 subunit alpha)SCN9A (Sodium channel protein type 9 subunit alpha)KCNH2 (Voltage-gated potassium channel subfamily H member 2)CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)SCN5A (Sodium channel protein type 5 subunit alpha)TRPV1 (Transient receptor potential cation channel subfamily V member 1)

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