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Drug intelligence / Profile preview
Promescent
- Development stage
- Phase 3
- Lead developer
- Absorption Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Promescent is a topical desensitizing spray containing lidocaine, specifically formulated for the treatment of premature ejaculation. It functions as a local anesthetic that reduces sensitivity in the penis by numbing the sensory nerves, thereby delaying ejaculation. Originally developed by Dr. Ron Gilbert, the product is marketed as an over-the-counter (OTC) drug under the FDA monograph for male genital desensitizing products. A Phase 3 clinical trial (NCT02241460) was conducted by Dr. Eugene Y. Rhee to evaluate its efficacy and safety compared to placebo.
- Brand names
- Promescent
- Other names
- Promescent Lidocaine Spray
02
Targets
GABRR (GABA-A receptor subunit rho)CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)TRPV1 (Transient receptor potential cation channel subfamily V member 1)SCN2A (Voltage-gated sodium channel protein type 2 subunit alpha)SCN5A (Sodium channel protein type 5 subunit alpha)SCN9A (Sodium channel protein type 9 subunit alpha)SCN10A (Sodium channel protein type X alpha subunit)KCNH2 (Voltage-gated potassium channel subfamily H member 2)
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