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promethazine + phenylephrine + codeine
- Development stage
- Approved
- Lead developer
- GSK
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Promethazine + phenylephrine + codeine is an oral combination drug consisting of **promethazine** (a first-generation antihistamine of the phenothiazine class and an H1 receptor antagonist), **phenylephrine** (a sympathomimetic decongestant and alpha-1 adrenergic receptor agonist), and **codeine** (an opioid analgesic and antitussive agent). This formulation is indicated for the temporary relief of cough, nasal congestion, runny nose, sneezing, and related symptoms caused by allergies or the common cold. Promethazine reduces allergic symptoms by blocking H1 histamine receptors; phenylephrine constricts nasal blood vessels via alpha-1 adrenergic receptor activation to relieve congestion; codeine acts as a mu-opioid receptor agonist in the central nervous system to suppress the cough reflex[1][3][7][11][12].
- Brand names
- Promethazine VC with CodeinePrometh VC with CodeinePentazine VC with CodeinePhenergan VC with Codeine
- Other names
- promethazine/phenylephrine/codeine
02
Targets
ADRA1A (α1A)MOR (Mu opioid receptor)HRH1 (Histamine H1 Receptor)
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