propantheline

Propantheline is a small molecule antimuscarinic (anticholinergic) agent used primarily to treat or prevent spasms in the muscles of the gastrointestinal tract (such as in irritable bowel syndrome), peptic ulcer disease, urinary incontinence, hyperhidrosis (excessive sweating), and other conditions involving smooth muscle spasm. It works by blocking muscarinic acetylcholine receptors on smooth muscle cells and secretory glands, thereby inhibiting involuntary contractions and reducing secretions such as gastric acid and sweat. At higher doses it may also exhibit nicotinic effects resulting in neuromuscular blockade. The drug is typically administered orally as propantheline bromide. Propantheline has been largely replaced by newer agents for many indications but remains available for certain uses. It is sometimes prescribed off-label for excessive salivation during dental procedures. Its side effect profile includes typical anticholinergic effects such as dry mouth, blurred vision, constipation, tachycardia, urinary retention and decreased sweating.

Brand names

Pro-BanthinePro Banthine

Other names

propantheline bromidePropantelina bromuroPropanthelin bromidPropanthelini Bromidum