Drug intelligence / Profile preview

Propel Nova Sinus Implant

Development stage
Unknown
Lead developer
Intersect ENT
Modality
Implantable Devices → Device-based Delivery → Drug Delivery Systems
Administration
Intranasal (implantation Into Sinus Cavity)
01

Overview

The **Propel Nova Sinus Implant**, later renamed **Propel Contour Sinus Implant**, is a bioabsorbable, drug-eluting sinus implant developed for use in adult patients ≥18 years of age to maintain sinus ostial patency following sinus surgery and to locally deliver the corticosteroid **mometasone furoate**. It is primarily indicated to reduce post-operative inflammation, scarring, and the need for further intervention in patients with chronic rhinosinusitis. The implant delivers sustained release of **mometasone furoate** directly to the sinus mucosa over ~30 days as the device gradually bioabsorbs over 30–45 days. Its mechanism combines physical stenting to separate/dilate mucosal tissue with localized corticosteroid anti-inflammatory action. The implant was developed by Intersect ENT and is now manufactured/marketed by Medtronic.

Brand names
Propel Nova Sinus Implant
Other names
Propel Contour Sinus ImplantPropel Nova
02

Targets

GR (Glucocorticoid receptor)

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