Propess

Propess is a controlled-release vaginal delivery system containing 10 mg of dinoprostone (prostaglandin E2), used for the initiation of cervical ripening in women at term (from 37 completed weeks of gestation). The device consists of a non-biodegradable polymeric matrix that releases approximately 0.3 mg/hour of dinoprostone over up to 24 hours. Dinoprostone acts locally on the cervix by increasing collagenase activity, leading to softening and dilation—a process known as cervical ripening—thereby facilitating labor induction. The mechanism involves binding to prostaglandin E2 receptors in cervical tissue and myometrium, promoting enzymatic changes and uterine contractions. Propess is administered intravaginally by qualified healthcare professionals in hospital settings with continuous fetal and uterine monitoring[1][3][7].

Brand names

Propess

Other names

dinoprostone vaginal delivery systemdinoprostone vaginal insertPROPESS 10 mg vaginal delivery systemPROPESS10 mg vaginal delivery systemPROPESS-10 mg vaginal delivery system