propionyl l-carnitine hydrochloride

Propionyl L-carnitine hydrochloride is a derivative of L-carnitine and acts as an orally active cardiovascular agent. It is primarily used for the treatment of peripheral arterial occlusive disorders and has been studied for other indications such as heart failure and ulcerative colitis. Mechanistically, it stimulates energy production in ischemic muscles by increasing citric acid cycle flux and stimulating pyruvate dehydrogenase activity. It also acts as a free radical scavenger and improves coagulative fibrinolytic homeostasis in vascular endothelium. Propionyl L-carnitine enhances ATP generation by facilitating fatty acid transport into mitochondria for beta-oxidation. Clinical studies have shown benefits in improving walking distance in patients with peripheral arterial disease and potential improvements in quality of life for those with exercise intolerance due to chronic heart failure or vascular disease[4][5][6][9].

Brand names

Dromos

Other names

propionyl-L-carnitinepropionyl-L-carnitine HCllevocarnitine propionate hydrochloridelevocarnitine proprionate(R)-propionyl carnitine chloride(2R)-3-carboxy-N,N,N-trimethyl-2-(propionyloxy)propan-1-aminium chlorideMFCD00274137MFCD-00274137MFCD 00274137