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Drug intelligence / Profile preview
Propofan
- Development stage
- Unknown
- Lead developer
- FRiLAB
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Propofan is a combination analgesic developed and marketed by FRiLAB. The current formulation ("nouvelle formule") is a Tier 2 analgesic containing paracetamol (acetaminophen), codeine phosphate hemihydrate, and caffeine. It is approved for the treatment of moderate to severe pain, including musculoskeletal pain, neuralgia, migraine, and headache. Historically, the brand name Propofan was used for a combination of paracetamol, dextropropoxyphene, and caffeine, which was widely prescribed in Europe but withdrawn from the market in 2011 due to safety concerns associated with dextropropoxyphene.
- Brand names
- Propofan
- Other names
- caffeine + codeine + paracetamolcaffeine + codeine phosphate + paracetamolcaffeine + codeine phosphate hemihydrate + paracetamolparacetamol + codeine + caffeineparacetamol + codeine phosphate + caffeineparacetamol + codeine phosphate hemihydrate + caffeine
02
Targets
ADORA1 (Adenosine receptor A1 subtype)ADORA2A (Adenosine A₂A Receptor)MOR (Mu opioid receptor)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)
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