Drug intelligence / Profile preview

PropoFlo

Development stage
Unknown
Lead developer
AstraZeneca
Modality
Small Molecules
Administration
Intravenous
01

Overview

PropoFlo is a branded intravenous formulation of propofol, a short-acting sedative–hypnotic anesthetic used for induction and maintenance of general anesthesia and for procedural or ICU sedation. Propofol acts primarily as a positive allosteric modulator and, at higher concentrations, agonist at GABA-A receptors, enhancing inhibitory neurotransmission in the central nervous system and producing rapid loss of consciousness with quick recovery due to rapid redistribution and metabolism. It is supplied as a sterile lipid emulsion for IV use and is typically employed in operating rooms, procedural suites, and intensive care units to provide controlled, titratable sedation or anesthesia.

Brand names
PropoFlo
Other names
PropofolVetpropofol injectable emulsion (veterinary)generic propofol for dogs
02

Targets

GABRB3 (GABA-A receptor subunit beta-3)GABRR (GABA-A receptor subunit rho)GABRB2 (GABA-A receptor subunit beta-2)GABA-B (Gamma-aminobutyric acid receptor type B)

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