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propofol + fentanyl + atracurium besylate
- Development stage
- Unknown
- Lead developer
- Mansoura University
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Propofol + fentanyl + atracurium besylate is a combination anesthetic regimen used for the induction and maintenance of general anesthesia. Propofol is a short-acting intravenous sedative-hypnotic that acts as a positive allosteric modulator of the GABA-A receptor. Fentanyl is a potent synthetic opioid analgesic that primarily targets the mu-opioid receptor. Atracurium besylate is a non-depolarizing neuromuscular blocking agent that acts as a competitive antagonist at nicotinic acetylcholine receptors at the neuromuscular junction. This combination provides the three pillars of general anesthesia: hypnosis, analgesia, and muscle relaxation. In clinical trial contexts, such as those conducted by Mansoura University, this regimen is used as a standard anesthetic control for procedures like abdominoplasty to evaluate the efficacy of regional nerve blocks for postoperative pain management.
- Other names
- propofol + fentanyl + atracurium
02
Targets
GABRR (GABA-A receptor subunit rho)Muscle-type nicotinic acetylcholine receptorMOR (Mu opioid receptor)
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