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propofol + rocuronium + fentanyl + morphine + volatile anesthetic + bupivacaine + adrenaline
- Development stage
- Unknown
- Lead developer
- Meir Medical Center
- Modality
- Small Molecules
- Administration
- Intravenous, Local Infiltration
01
Overview
This general anesthesia protocol is a multi-drug regimen utilized in clinical research at Meir Medical Center, specifically for patients undergoing total knee arthroplasty (TKA). The protocol consists of an induction phase using **propofol** (GABA-A receptor agonist), **rocuronium** (neuromuscular blocker), **fentanyl**, and **morphine** (opioid analgesics). Maintenance of anesthesia is achieved through a **volatile anesthetic**. To address postoperative pain, the protocol also incorporates a high-volume local anesthesia infiltration (LIA) consisting of **bupivacaine** (a sodium channel blocker) and **adrenaline** (an adrenergic agonist used to prolong the local effect). This specific combination is studied to compare its efficacy in postoperative pain management and physical therapy outcomes against spinal anesthesia techniques.
- Other names
- general anesthetic-Meir Medical Center-postoperative painGeneral Anesthesia Protocol (Meir Medical Center)
02
Targets
GABRR (GABA-A receptor subunit rho)ADRA1A (α1A)Nicotinic Acetylcholine ReceptorMOR (Mu opioid receptor)DOR (Opioid Receptor Delta 1)KOR (Kappa opioid receptor)Glycine receptor
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