propofol + sodium chloride

Propofol + sodium chloride refers to a combination product in which propofol, an intravenous general anesthetic and sedative-hypnotic agent, is formulated with sodium chloride as part of its injectable emulsion. Propofol acts primarily by potentiating the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) at GABAA receptors in the central nervous system, resulting in sedation and anesthesia. It is widely used for induction and maintenance of general anesthesia, procedural sedation, and intensive care unit (ICU) sedation of intubated patients. Sodium chloride serves as an excipient to adjust tonicity or pH but does not contribute pharmacologically to the anesthetic effect[1][3][5]. The emulsion may also contain other excipients such as soybean oil, egg lecithin, glycerol, disodium edetate (EDTA), and water for injection[3][8]. The combination is administered intravenously under strict medical supervision due to risks including respiratory depression, hypotension, pain on injection site, risk of infection from lipid emulsion contamination, and rare but serious complications like propofol infusion syndrome[4][5].

Brand names

DiprivanPropofol-Lipuro

Other names

propofol and sodium chloridepropofol with NaClpropofol plus sodium chloride