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Drug intelligence / Profile preview
propolis flavonoid extract
- Development stage
- Preclinical
- Lead developer
- Cairo University
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Propolis flavonoid extract is a flavonoid-rich preparation derived from propolis, a resinous substance collected by honeybees. It is being investigated for its immunomodulatory and anti-inflammatory properties, specifically its ability to inhibit Toll-like receptor 4 (TLR4) signaling and suppress the production of pro-inflammatory cytokines such as interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). Research conducted by Cairo University has focused on its potential to regulate inflammatory responses in human periodontal ligament stem cells (PDLSCs) under lipopolysaccharide (LPS)-induced stress, suggesting a therapeutic role in managing periodontal diseases and other inflammatory conditions.
- Other names
- Flavonoid extract from propolispropolis-derived flavonoid extract
02
Targets
AHR (Aryl hydrocarbon receptor)IL1B (Interleukin-1 beta)IL-6 (Interleukin 6)MEKMYD88 (Myeloid differentiation primary response protein MyD88)TNFRSF11A (RANK)TLR2 (Toll-like Receptor 2)TLR3 (Toll-like receptor 3)TLR4 (Toll-like receptor 4)TNFA (Tumor necrosis factor alpha (soluble))
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