Drug intelligence / Profile preview

propranolol + salbutamol

Development stage
Discontinued
Lead developer
AkzoNobel
Modality
Small Molecules
Administration
Oral, Intravenous, Inhalation, Intramuscular, Subcutaneous, Rectal
01

Overview

propranolol + salbutamol is an unbranded combination of two active pharmaceutical ingredients: propranolol—a non-selective beta-adrenergic antagonist (beta blocker)—and salbutamol (also known as albuterol)—a short-acting beta-2 adrenergic agonist (bronchodilator)[1][3][5][9]. **Propranolol** works by antagonizing beta-adrenergic receptors (both beta-1 and beta-2), reducing heart rate, blood pressure, and symptoms related to excess sympathetic activity[1][3][2][4][8]. **Salbutamol** stimulates beta-2 adrenoceptors in airway smooth muscle, causing bronchodilation and symptom relief in asthma and COPD[5][9]. Combining propranolol and salbutamol is unusual in clinical practice, as propranolol can antagonize the bronchodilatory effect of salbutamol, potentially causing respiratory complications in patients with asthma or COPD[3][7][6]. However, propranolol may be considered in treating adverse cardiovascular or metabolic effects of salbutamol overdose in non-asthmatic patients[7]. No specific commercial developer or brand name is referenced for this combination.

Other names
propranolol + albuterol
02

Targets

HTR1B (5-Hydroxytryptamine Receptor 1B)ADRB1 (β1)ADRB2 (β2)

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