Drug intelligence / Profile preview

prosopis cineraria pod extract

Development stage
Preclinical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Topical
01

Overview

**Prosopis cineraria pod extract** is a botanical extract obtained from the mature or immature pods of the Prosopis cineraria tree, which is native to arid regions of South Asia and the Middle East. Traditionally used in Ayurvedic and Unani medicine, the extract is claimed to have a wide range of pharmacological effects including antihyperlipidemic, antihyperglycemic, antioxidant, analgesic, anti-inflammatory, and antibacterial activities. Modern research suggests that ethanolic extracts of the pods can lower serum cholesterol levels, decrease atheromatous plaque formation, enhance antioxidant enzyme activity and inhibit HMG-CoA reductase, a key enzyme in cholesterol biosynthesis[2]. In vitro and animal studies have demonstrated the ability of prosopis cineraria pod extracts (especially ethyl acetate and n-butanol fractions) to inhibit α-glucosidase and α-amylase, suggesting a role in glycemic control[1]. Pods are also used in traditional medicine for earaches, toothaches, and as a vegetable[1][4]. The extract’s mechanism of action appears to primarily involve inhibition of carbohydrate digestive enzymes, antioxidative effects, and possibly HMG-CoA reductase inhibition. No major pharmaceutical company markets the extract as an approved drug; it is mainly used as a traditional herbal remedy and dietary supplement.

Other names
khejri pod extractP. cineraria pod extract
02

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)AMY (Pancreatic alpha-amylase)Sucrase-Isomaltase

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