prostaglandin J2

Prostaglandin J2 (PGJ2) is an endogenous cyclopentenone prostaglandin and a downstream metabolite of prostaglandin D2. It is produced during inflammation in humans and has been implicated in both physiological and pathological processes. Mechanistically, PGJ2 can induce oxidative stress, disrupt the cytoskeleton, trigger neuronal apoptosis, and promote the accumulation of ubiquitinated proteins into aggregates. These effects are particularly relevant to neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease[1][4][7][8]. The molecule contains a reactive α,β-unsaturated carbonyl group that allows it to form covalent adducts with cysteine residues on proteins, affecting protein function[8]. While some derivatives of PGJ2 (notably 15-deoxy-delta12,14-prostaglandin J2) act as ligands for peroxisome proliferator–activated receptor gamma (PPARγ), modulating inflammation and adipocyte differentiation[4], native PGJ2 itself is highly neurotoxic compared to other prostaglandins[7][8].

Other names

prostaglandin J2PGJ2PGJ-2PGJ 29-Deoxy-delta-9-prostaglandin D29-Deoxy-delta-9-pgd2