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Prostakan forte
- Development stage
- Unknown
- Lead developer
- Schwabe
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Prostakan forte is an approved herbal medicinal product (phytopharmaceutical) developed by Dr. Willmar Schwabe. It is a fixed-dose combination of two standardized plant extracts: Sabal serrulata (saw palmetto) fruit extract (WS 1473) and Urtica dioica (stinging nettle) root extract (WS 1031). Prostakan forte is primarily indicated for the treatment of lower urinary tract symptoms (LUTS) associated with early-stage (stages I and II) benign prostatic hyperplasia (BPH). The combination of extracts exerts synergistic antiandrogenic, anti-inflammatory, and anti-edematous effects. Mechanistically, it inhibits the enzymes 3-oxo-5-alpha-steroid 4-dehydrogenase (5-alpha reductase) and aromatase, thereby reducing the conversion of testosterone to dihydrotestosterone (DHT) and limiting prostate tissue proliferation.
- Brand names
- ProstakanProstakan forteProstaguttProstagutt forteProstaplantProstaplant-F
- Other names
- sabal serrulata extract + urtica dioica extractsaw palmetto extract + stinging nettle root extract
02
Targets
CACNA1S (Voltage-dependent L-type calcium channel subunit alpha-1S)SRD5A2 (Steroid 5-alpha-reductase type II)SRD5A1 (Steroid 5-alpha-reductase type 1)mAChR (Muscarinic acetylcholine receptors)TRPV1 (Transient receptor potential cation channel subfamily V member 1)ADRA1A (α1A)
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