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Drug intelligence / Profile preview
Prostasan
- Development stage
- Unknown
- Lead developer
- A. Vogel
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Prostasan is a standardized herbal extract derived from the berries of the saw palmetto plant (*Serenoa repens*), developed by A. Vogel. It is primarily indicated for the relief of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). The extract's mechanism of action is multi-factorial, involving the inhibition of 5-alpha-reductase (which reduces the conversion of testosterone to dihydrotestosterone), competitive antagonism of androgen receptors, and anti-inflammatory activity via the inhibition of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) pathways. Clinical research, including open-label pilot trials, has also explored its efficacy in improving sexual dysfunction, such as erectile function and libido, in men suffering from BPH symptoms.
- Brand names
- Prostasan
- Other names
- Saw palmetto berry extractSerenoa repens extractSabal serrulata extract
02
Targets
SRD5A (Steroid 5-alpha-reductase)ALOX5 (Arachidonate 5-lipoxygenase)EGFR (Epidermal growth factor receptor)COXAR (Adrenergic receptors)
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