protease inhibitors + nucleoside reverse transcriptase inhibitors

This is a **combination of two classes of antiretroviral medications** used in the treatment of HIV infection. **Protease inhibitors** (PIs) act by binding to the catalytic site of the HIV protease enzyme, blocking the cleavage of viral polyproteins, which is essential for producing mature infectious viral particles. **Nucleoside reverse transcriptase inhibitors** (NRTIs) are nucleotide analogues that inhibit reverse transcription by incorporating into viral DNA during synthesis and causing chain termination. This combination forms part of highly active antiretroviral therapy (HAART) and may be used with or without the addition of other agent classes such as NNRTIs.

Other names

protease inhibitors + nucleoside reverse transcriptase inhibitors