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Drug intelligence / Profile preview
protein disulfide isomerase-related protein
- Development stage
- Preclinical
- Lead developer
- Soochow University
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
Protein disulfide isomerase-related protein (PDIr), also known as PDIA5, is an endoplasmic reticulum-resident enzyme belonging to the protein disulfide isomerase (PDI) family. Recombinant PDIr is being investigated as a novel antithrombotic and antiplatelet therapeutic agent for the treatment and prevention of arterial thrombosis. Mechanistically, PDIr acts as a disulfide reductase that dual-inhibits platelet function and coagulation activation. It physically interacts with integrin alpha-IIb/beta-3 (GPIIb/IIIa) on the platelet surface, reducing the alpha-IIb disulfide bond (Cys146-Cys167) to suppress integrin activation and platelet aggregation. Additionally, PDIr binds to and cleaves disulfide bonds within prothrombin, preventing its binding to platelet phosphatidylserine and thereby attenuating thrombin generation and procoagulant activity.
- Other names
- PDIA5PDIA-5PDIA 5PDIRprotein disulfide-isomerase A5recombinant protein disulfide isomerase-related protein
02
Targets
GPIIb/IIIa (Integrin alpha-IIb/beta-3)F2 (Thrombin)
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