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prothromplex total
- Development stage
- Phase 4
- Lead developer
- Takeda
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
TAK-330 (prothromplex total) is an investigational intravenous medication developed as a four-factor prothrombin complex concentrate (4F-PCC) for the urgent reversal of anticoagulation in patients treated with direct oral Factor Xa inhibitors such as rivaroxaban, apixaban, or edoxaban who require emergency surgery or invasive procedures. It contains human coagulation factors II, VII, IX, and X as well as protein C and is designed to restore normal blood clotting by replenishing these essential clotting factors that are inhibited by Factor Xa inhibitors. The drug is being evaluated in phase 3 clinical trials for its efficacy and safety compared to standard 4F-PCC therapy in managing bleeding risks during urgent surgical interventions[1][2][3][5][8].
- Other names
- prothromplex totalfour-factor prothrombin complex concentrate4F-PCC
02
Targets
F7 (Coagulation Factor VII)F2 (Thrombin)F9 (Coagulation Factor IX)F10 (Factor Xa)
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