proxibarbal

Proxibarbal is a barbiturate derivative that functions as a sedative and enzyme inducer, notably lacking the potent hypnotic effects typical of the barbiturate class. It exists in a rapid tautomeric equilibrium with valofan (2-allophanyl-2-allyl-gamma-valerolactone), which acts as its cerebral prodrug. Historically, it has been utilized in the treatment of migraine, menopausal psycho-neuro-autonomic disorders, and various psychosomatic conditions. While it was investigated for the prophylaxis of gastro-duodenal ulcer recurrence, clinical trials did not demonstrate statistical significance. A significant clinical concern associated with its use is the development of immuno-allergic thrombocytopenia.

Brand names

IpronalCentralgolVasalgin

Other names

proxybarbital5-allyl-5-(2-hydroxypropyl)barbituric acid