PRS CK STORM

PRS CK STORM is an allogeneic biological medicinal product designed to prevent and treat cytokine storm associated with moderate to severe infectious processes, including COVID-19. It is a standardized conditioned medium produced by indirect contact co-culture of M2-polarized macrophages (derived from donor monocytes) with mesenchymal stromal cells (MSCs) from adipose tissue, also sourced from different donors. The resulting secretome contains human proteins—primarily cytokines, chemokines, and growth factors—intended to exert anti-inflammatory and antifibrotic effects by immunoregulating the innate immune system and improving coordination with adaptive immunity. Preclinical studies have demonstrated its safety and high efficacy in reducing acute inflammation in animal models of cytokine storm, showing superior results compared to Anakinra. Clinical trials are ongoing for intravenous administration in hospitalized patients with COVID-19 at risk for or experiencing cytokine storm[2][3][4][5].

Brand names

PRS CK STORM