prucalopride

Prucalopride is a selective, high-affinity serotonin 5-HT4 receptor agonist used primarily for the treatment of chronic idiopathic constipation (CIC) in adults. By stimulating 5-HT4 receptors located throughout the gastrointestinal tract—especially in smooth muscle cells, enterochromaffin cells, and the myenteric plexus—prucalopride enhances peristalsis and increases colonic motility. This action accelerates colonic transit time and promotes more frequent spontaneous complete bowel movements. Prucalopride’s selectivity for 5-HT4 over other serotonin receptors reduces cardiovascular risks associated with earlier drugs in this class. It also accelerates gastric emptying and small bowel transit. The drug was developed to address impaired motility associated with chronic constipation that is not caused by other diseases or medications[1][2][3][4][6][8].

Brand names

MotegrityResolor

Other names

prucaloprideTA211TA-211TA 211