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Prulgliptin is an orally active, small molecule dipeptidyl peptidase-4 (DPP-4) inhibitor developed by CSPC Pharmaceutical Group for the treatment of type 2 diabetes mellitus. By inhibiting the DPP-4 enzyme, prulgliptin prevents the degradation of incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This leads to increased insulin secretion and suppressed glucagon release in a glucose-dependent manner, effectively lowering blood glucose levels. Prulgliptin is being developed as both a monotherapy and in fixed-dose combinations with other antidiabetic agents like metformin.
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