Drug intelligence / Profile preview

prulgliptin

Development stage
Unknown
Lead developer
CSPC Pharmaceutical Group
Modality
Small Molecules
Administration
Oral
01

Overview

Prulgliptin is an orally active, small molecule dipeptidyl peptidase-4 (DPP-4) inhibitor developed by CSPC Pharmaceutical Group for the treatment of type 2 diabetes mellitus. By inhibiting the DPP-4 enzyme, prulgliptin prevents the degradation of incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This leads to increased insulin secretion and suppressed glucagon release in a glucose-dependent manner, effectively lowering blood glucose levels. Prulgliptin is being developed as both a monotherapy and in fixed-dose combinations with other antidiabetic agents like metformin.

Other names
普鲁格列汀
02

Targets

DPP7 (Dipeptidyl peptidase 7)DPP9 (Dipeptidyl Peptidase 9)DPP8 (Dipeptidyl peptidase 8)FAP (Fibroblast activation protein alpha)

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