prulifloxacin

Prulifloxacin is a broad-spectrum, synthetic fluoroquinolone antibiotic used for the treatment of various bacterial infections. It is administered orally and acts as a prodrug, being rapidly metabolized in the body to its active form, ulifloxacin[2][7][8]. Prulifloxacin exerts its antibacterial effect by inhibiting bacterial DNA gyrase and topoisomerase IV—enzymes essential for DNA replication, transcription, repair, and recombination[1][3][6]. This dual inhibition disrupts bacterial cell division and leads to cell death. The drug demonstrates good tissue penetration and has a long elimination half-life that allows once-daily dosing[2][7]. Prulifloxacin has been approved in several countries (including Italy, Japan, China, India, Greece) for indications such as acute uncomplicated lower urinary tract infections (simple cystitis), complicated lower urinary tract infections, acute exacerbations of chronic bronchitis (respiratory tract infections), and gastroenteritis including infectious diarrheas[3][5]. It is not approved in the United States.

Brand names

PRULIFLOX 600PRULIFLOX600PRULIFLOX-600

Other names

ulifloxacin