Drug intelligence / Profile preview

Prunelax

Development stage
Unknown
Lead developer
Megalabs Group
Modality
Small Molecules
Administration
Oral
01

Overview

Prunelax (also marketed as Ciruelax) is an over-the-counter natural stimulant laxative used for the relief of occasional constipation. Its primary active ingredient is senna leaf extract, which contains sennosides. These sennosides are prodrugs that pass through the upper gastrointestinal tract and are hydrolyzed by colonic bacteria into active rheinanthrones. These active metabolites stimulate the myenteric plexus, increasing peristaltic contractions and altering water and electrolyte transport across the intestinal wall to promote bowel movements. The product also contains dried prune extract and is available in various strengths, including Regular and Maximum Relief tablets, typically providing relief within 8 to 12 hours. It is marketed as a vegan, gluten-free herbal product.

Brand names
PrunelaxCiruelax
02

Targets

ATP1A (Sodium/potassium-transporting ATPase)AQP3 (Aquaporin-3 channel protein)

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