Drug intelligence / Profile preview

Prunella oral liquid

Development stage
Preclinical
Lead developer
Shandong Xianhe Pharmaceutical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Prunella oral liquid is an herbal preparation derived from the plant Prunella vulgaris, also known as self-heal or Xiakucao in Chinese. It is used in traditional Chinese medicine and is being studied for its therapeutic effects on thyroid conditions. A clinical trial (NCT06423235) is currently evaluating its efficacy and safety for treating benign thyroid nodules. This is a post-marketing study, suggesting the product is already available in China, where it is used to treat conditions like goiter, thyroid nodules, and hyperthyroidism. The proposed mechanisms of action for Prunella vulgaris involve anti-inflammatory and immunomodulatory effects, potentially through the suppression of pathways like NF-κB and the regulation of apoptosis and oxidative stress. The plant contains numerous bioactive compounds, including triterpenoids, flavonoids (such as luteolin, quercetin, kaempferol), and phenolic acids (like rosmarinic acid), which are thought to contribute to its medicinal properties.

Brand names
JiRui
Other names
Xiakucao koufuyeSelf-heal oral liquid夏枯草口服液
02

Targets

JUN (Transcription factor Jun)TNFA (Tumor necrosis factor alpha (soluble))

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