PRX167700

PRX167700 is an oral small molecule anti-inflammatory drug that acts as a selective inhibitor of vascular adhesion protein‑1 (VAP‑1), also known as semicarbazide-sensitive amine oxidase (SSAO, AOC3). By inhibiting this enzyme, which is involved in the movement of immune cells from the blood into sites of inflammation, the drug aims to reduce inflammatory processes and relieve symptoms associated with chronic inflammatory conditions. Its primary clinical development has focused on osteoarthritis of the knee, particularly in patients who are inappropriate for oral nonsteroidal anti-inflammatory therapy. The mechanism suggests potential disease-modifying effects by limiting further joint damage through reduced immune cell infiltration[1][2][4][5].

Other names

PRX167700PRX-167700PRX 167700PRO VAP-1 inhPRX 167700HPRX167700HPRX-167700H