Drug intelligence / Profile preview

pseudoephedrine

Development stage
Approved
Lead developer
GSK
Modality
Small Molecules
Administration
Oral
01

Overview

Pseudoephedrine is a sympathomimetic amine and decongestant used to relieve nasal and sinus congestion caused by colds, allergies, hay fever, or sinusitis. It works primarily as an agonist at alpha adrenergic receptors (and to a lesser extent beta adrenergic receptors), causing vasoconstriction in the nasal mucosa which reduces swelling and congestion. Pseudoephedrine also acts as a norepinephrine releasing agent, indirectly stimulating adrenergic receptors throughout the body. It is taken orally and is available both alone and in combination with other medications for symptomatic relief of upper respiratory tract conditions[1][2][3][4][5].

Brand names
SudafedChlor Trimeton Nasal DecongestantContac ColdDrixoral Decongestant Non-DrowsyElixsure DecongestantEntex
Other names
pseudoephedrine hydrochloride
02

Targets

NET (Norepinephrine Transporter)ADRA1 (Alpha-1 adrenergic receptor family)ADRB1 (β1)

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