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Pseudomonas aeruginosa bacteriophage is an investigational biologic (phage therapy) being developed by the Respiratory Department at The Children's Hospital at Westmead, Australia, in collaboration with the Westmead Institute of Medical Research. This personalized medicine approach utilizes obligate lytic bacteriophages specifically selected to target and lyse a patient's individual *Pseudomonas aeruginosa* sputum isolates. It is currently being evaluated in a Phase 1 clinical trial for the treatment of chronic *Pseudomonas aeruginosa* lung infections in children and adolescents with cystic fibrosis, non-CF bronchiectasis, and chronic suppurative lung disease. The therapy is administered via both intrabronchial instillation and nebulisation to ensure direct delivery to the site of infection.
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