pseudoprotodioscin

**Pseudoprotodioscin** is a steroidal saponin primarily isolated from plants such as *Dioscorea panthaica*, *Smilax menispermoidea*, and some species of Tribulus and Trigonella[1][4][7]. It exhibits multiple biological activities, including anti-inflammatory, cytotoxic, anti-adipogenic, and putative estrogenic activity. Mechanistic studies suggest pseudoprotodioscin acts partially via modulation of estrogen receptor alpha (ERα), leading to increased nuclear accumulation and expression of ERα and endothelial nitric oxide synthase (eNOS) in endothelial and adipose tissues, which in turn reduces atherosclerotic lesion formation, cholesterol, and triglyceride levels in animal models[1][6]. It also inhibits SREBP1/2-mediated lipogenesis and suppresses production of inflammatory cytokines such as TNF-α[1][4][15][16]. In cancer cell assays, pseudoprotodioscin displays moderate cytotoxicity and inhibits melanogenesis and inflammatory signaling such as NF-κB[1][4][15].

Other names

Oligofurostanoside ACB4XAC5WHSCB-4XAC5WHSCB 4XAC5WHSDTXSID101315996DTXSID-101315996DTXSID 101315996(3beta,25R)-26-(beta-D-glucopyranosyloxy)furosta-5,20(22)-dien-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1->2)-O-(6-deoxy-alpha-L-mannopyranosyl-(1->4))-beta-D-glucopyranosidePROTOGRACELLINPSEUDOPROTOTRIBESTINPROTODIOSCIN, PSEUDOβ-D-Glucopyranoside, (3β,25R)-26-(β-D-glucopyranosyloxy)furosta-5,20(22)-dien-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-