pseudosemiglabrin

Pseudosemiglabrin is a natural prenylated flavone isolated from the aerial parts of *Tephrosia* species, including *Tephrosia apollinea*, *Tephrosia semiglabra*, and *Tephrosia purpurea*. It has been investigated preclinically for its potential therapeutic applications in oncology, inflammatory diseases, epilepsy, and acute pancreatitis. In breast cancer models, pseudosemiglabrin exhibits chemopreventive and antiangiogenic properties by inhibiting VEGF expression, VEGFR phosphorylation, and the Notch pathway, as well as acting as an inhibitor of aromatase and the estrogen receptor. Additionally, it has demonstrated anti-inflammatory effects through selective COX-2 inhibition and reduction of pro-inflammatory cytokines (TNF-alpha, IL-1beta), and neuroprotective/anti-epileptic properties by modulating GABAergic and glutamatergic neurotransmission.

Other names

(-)-pseudosemiglabrinpseudo semiglabrinpseudosmiglabrin