Drug intelligence / Profile preview

pseudostellaria heterophylla polysaccharides

Development stage
Preclinical
Lead developer
Fujian University of Traditional Chinese Medicine
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Pseudostellaria heterophylla polysaccharides are bioactive macromolecular compounds extracted from the dried tuberous roots of *Pseudostellaria heterophylla* (commonly known as Taizishen or Prince Ginseng). These polysaccharides, which include specific purified fractions such as PF40 and H-1-2, exhibit a range of pharmacological properties, including immunomodulation, anti-diabetic effects, anti-fatigue activity, and neuroprotection. Preclinical studies demonstrate that they can alleviate insulin resistance, restore Th17/Treg cell balance, protect the intestinal mucosal barrier, and modulate the gut microbiota. Additionally, they have shown potential in mitigating Alzheimer's-like pathology via the microbiota-gut-brain axis and enhancing physical endurance by reducing oxidative stress.

Other names
H-1-2H1-2H 1-2PF40PF-40PF 40PH-PSPHPPPHPRPPrince Ginseng polysaccharidesPseudostellaria heterophylla polysaccharidePseudostellaria heterophylla polysaccharidesTaizishen polysaccharides
02

Targets

IKBKE (IκB kinase epsilon)MYD88 (Myeloid differentiation primary response protein MyD88)NF-κBSIRT1 (NAD-dependent protein deacetylase sirtuin-1)TLR4 (Toll-like receptor 4)

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