Drug intelligence / Profile preview

psiguavin

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Psiguavin is a natural compound belonging to the family of hydrolyzable tannins, extracted from the guava plant (Psidium guajava). It is being investigated as a potential treatment for obesity and overweight by acting as an inhibitor of pancreatic lipase, the primary enzyme responsible for dietary lipid digestion. Preliminary studies suggest a strong interaction between psiguavin and the active site of pancreatic lipase, leading to a reduction in dietary calorie intake, similar to the approved obesity drug orlistat. While traditionally used for liver fat accumulation, its efficacy for obesity is currently being evaluated in clinical trials.

02

Targets

PNLIP (Pancreatic triacylglycerol lipase)

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