psilocybe cubensis

*Psilocybe cubensis* is a species of psychedelic mushroom whose principal active compounds are the alkaloids psilocybin and psilocin. Upon ingestion, psilocybin is rapidly dephosphorylated into psilocin, which acts as a high-affinity partial agonist at the serotonin 5-HT2A receptor. This interaction modulates glutamatergic neurotransmission in the prefrontal cortex, leading to profound alterations in consciousness and perception. In a clinical context, *Psilocybe cubensis* and its standardized extracts are being investigated for their potential to induce rapid and sustained antidepressant and anxiolytic effects, particularly in treatment-resistant populations. Research suggests that the "mystical-type experience" facilitated by these compounds may be a key mediator of therapeutic outcomes, potentially promoting neuroplasticity and the reorganization of dysfunctional neural circuits associated with mood and substance use disorders.

Other names

magic mushroomsgolden topscubesStropharia cubensisPsilocybe mushroom