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PsiThera-sTNFα
- Development stage
- Preclinical
- Lead developer
- PsiThera
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
PsiThera-sTNFα is an oral small-molecule inhibitor of soluble tumor necrosis factor alpha (sTNFα) currently in the discovery stage of development by PsiThera. Designed as an "Antibody-in-a-Pill," the therapeutic aims to provide the potent, high-affinity blockade of TNFα typically associated with injectable monoclonal antibodies but in a more convenient oral format. The program utilizes a proprietary platform that combines physics-based modeling, artificial intelligence, and structural biology to target complex cytokine systems where biologics have traditionally dominated. It is being developed for the treatment of autoimmune and inflammatory conditions, specifically within the fields of rheumatology and inflammatory bowel disease (IBD).
- Other names
- soluble TNF alphasTNFα (soluble TNFα)PsiThera-sTNFα (soluble TNF alpha)-small molecule-oral-Rheumatology-Inflammatory Bowel Disease
02
Targets
TNFA (Tumor necrosis factor alpha (soluble))
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